Xeomin®

Oh those annoying moderate to severe frown lines, crow’s feet and forehead wrinkles! XEOMIN (incobotulinumtoxinA) for injection, for shutterstock_115693471intramuscular use, is a prescription medication that is injected into facial muscles for the temporary improvement in the appearance of moderate to severe glabellar lines (frown lines) in adult patients.

How does XEOMIN work?

When you squint or frown, the muscles between your brows contract, causing the skin to furrow and fold. These lines that occur due to facial mimics are referred to as dynamic lines. Over time, as your skin ages and loses some of its elasticity, these repeated contractions can cause persistent frown lines.

Botulinum toxin type A—the active ingredient in XEOMIN—is used in facial aesthetic treatment to help treat dynamic lines like glabellar frown lines. It acts on nerve endings in muscles to prevent muscle fibers from contracting. By reducing these contractions, XEOMIN can temporarily reduce the frown lines on your forehead between your eyes.

Frequently Asked Questions

How do I know if XEOMIN is right for me?

If you are an adult with moderate to severe glabellar lines (frown lines between the eyes), XEOMIN may be right for you. Talk to your doctor to discuss the benefits and risks of treatment.

Do not take XEOMIN if you are allergic to botulinum toxin or any of the other ingredients in XEOMIN. You should also not take XEOMIN if you have had an allergic reaction to any other botulinum toxin product or have a skin infection at the planned injection site.

What can I expect during treatment?

During treatment, which usually takes about 10-20 minutes, your doctor will inject XEOMIN into the muscles in your forehead that cause frown lines between your brows. No anesthesia is required; however, your physician may use a topical anesthetic or cold pack to reduce any discomfort.

When can I expect to see results?

In clinical trials, some patients observed visible smoothing as early as 3-4 days after injection. The median first onset of effect was less than a week. The maximum effect occurred at 30 days. The typical duration of effect was up to 3 months in clinical trials but may last significantly longer or shorter in individual patients.

What is the most important information that I should know about XEOMIN?

XEOMIN may cause serious side effects that can be life-threatening. Call your doctor or get medical help right away if you have any of these problems after treatment with XEOMIN:

• Problems with swallowing, speaking, or breathing. These problems can happen hours to weeks after an injection of XEOMIN if the muscles that you use to breathe and swallow become weak after the injection. Death can happen as a complication if you have severe problems with swallowing or breathing after treatment with XEOMIN.
• People with certain breathing problems may need to use muscles in their neck to help them breathe. These patients may be at greater risk for serious breathing problems with XEOMIN.
• Swallowing problems may last for several months. People who cannot swallow well may need a feeding tube to receive food and water. If swallowing problems are severe, food or liquids may go into your lungs. People who already have swallowing or breathing problems before receiving XEOMIN have the highest risk of getting these problems.
• Spread of toxin effects. In some cases, the effect of botulinum toxin may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism.

The symptoms of botulism include:

» loss of strength and muscle weakness all over the body
» double vision
» blurred vision and drooping eyelids
» hoarseness or change or loss of voice
» trouble saying words clearly
» loss of bladder control
» trouble breathing
» trouble swallowing

These symptoms can happen hours to weeks after you receive an injection of XEOMIN.

Who should not take XEOMIN?

Do not take XEOMIN if you:

• are allergic to XEOMIN or any of the ingredients in XEOMIN.
• had an allergic reaction to any other botulinum toxin products such as rimabotulinumtoxinB (MYOBLOC®), onabotulinumtoxinA (BOTOX®, BOTOX® COSMETIC), or abobotulinumtoxinA (DYSPORT®).
• have a skin infection at the planned injection site.
• have allergies to any botulinum toxin product
• have had any side effect from any other botulinum toxin in the past
• have a breathing problem, such as asthma or emphysema
• have a history of swallowing problems or inhaling food or fluid into your lungs (aspiration)
• have bleeding problems
• have drooping eyelids
• have plans to have surgery
• have had surgery on your face
• are pregnant or plan to become pregnant. It is not known if XEOMIN can harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if XEOMIN passes into breast milk.
• It is not known whether XEOMIN is safe or effective in children.

What should I tell my doctor?

Especially tell your doctor if you:

• have received any other botulinum toxin product in the last four months
Medication Guide XEOMIN (Zeo-min) (incobotulinumtoxinA)
for injection, for intramuscular use
• have received injections of botulinum toxin such as rimabotulinumtoxinB (MYOBLOC®), onabotulinumtoxinA (BOTOX®, BOTOX® COSMETIC) and abobotulinumtoxinA (DYSPORT®) in the past. Be sure your doctor knows exactly which product you received. The dose of XEOMIN may be different from other botulinum toxin products that you have received.
• have recently received an antibiotic by injection
• take muscle relaxants
• take an allergy or cold medicine
• take a sleep medicine
• take a blood thinner medicine

What are the possible side effects of XEOMIN?

XEOMIN can cause serious side effects. See “What is the most important information I should know about XEOMIN?”

• XEOMIN may cause other serious side effects including allergic reactions. Symptoms of an allergic reaction to XEOMIN
may include: itching, rash, redness, swelling, wheezing, asthma symptoms, or dizziness or feeling faint. Tell your doctor or get medical help right away if you get wheezing or asthma symptoms, or if you get dizzy or faint.
The most common side effects of XEOMIN include:
• dry mouth
• discomfort or pain at the injection site
• tiredness
• headache
• neck pain
• muscle weakness
• eye problems, including: double vision, blurred vision, drooping
eyelids, swelling of your eyelids, and dry eyes. http://www.orlandoplasticsurgeryassociates.com/med-spa/xeomin/ http://www.orlandoplasticsurgeryassociates.com/med-spa/xeomin/ http://www.orlandoplasticsurgeryassociates.com/med-spa/xeomin/ http://www.orlandoplasticsurgeryassociates.com/med-spa/xeomin/Reduced blinking can also occur. Tell your doctor or get medical help right away if you have eye pain or irritation following treatment.
Tell your doctor if you have any side effect that bothers you or that does
not go away. These problems could make it unsafe for you to drive a car or do other dangerous activities.